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KMID : 0369819970270040265
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 4 p.265 ~ p.269
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Preparation and Evaluation of Inclusion Complex of Muscone with β-Cyclodextrin
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곽은선/Kwack ES
조인숙/이계원/지웅길/박대규/Cho IS/Lee GW/Jee UK/Park DK
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Abstract
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An inclusion complex of muscone with β?cyclodextrin (CD), as a solid form of muscone, was prepared to increase the solubility of muscone. The molar ratio of muscone to β?CD in complex was in the range of 1:1∼1:5 when prepared by freeze-drying method. The interaction of muscone with β?CD in solid state was investigated by Infrared (IR) spectroscopy and differential scanning calorimetry (DSC). IR and DSC studies between muscone?β?CD inclusion complex and physical mixture showed that muscone?β?CD inclusion complex was prepared stably. From the amount of muscone incorporated in the inclusion complex, it was found that the molar ratio of muscone : β?CD was 1:1. Relative spatial position of muscone and β?CD was observed by Hyperchem molecular modelling program.
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KEYWORD
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